"After investigating 3,618 brains, they found that amyloid accumulation was strongly linked with a decline in cognition; however, if the extent of tau aggregation was also taken into consideration, the relationship disappeared. Furthermore, the level of tau accumulation, but not amyloid, predicted age at onset of cognitive decline, disease duration and final score on a test of mental function. According to the researchers, this indicates that tau is the main driver of Alzheimer’s."
http://www.iflscience.com/brain/study-suggests-tau-not-amyloid-major-driver-alzheimers
This is actually a big deal. Maybe I have missed something in the past few years, but the last time I discussed Alzheimer's, the tau hypothesis and the amyloid hypothesis were being debated. TBH, this has been going on for like decades now so I found it kinda boring, but if we can focus on one thing...
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