“In a new study published today in Science, researchers at San Diego State University and the Salk Institute for Biological Studies found that by limiting the time span during which fruit flies could eat, they could prevent aging- and diet-related heart problems. The researchers also discovered that genes responsible for the body's circadian rhythm are integral to this process, but they're not yet sure how.
Previous research has found that people who tend to eat later in the day and into the night have a higher chance of developing heart disease than people who cut off their food consumption earlier...
Next, the researchers sequenced the RNA of the flies at various points in the experiment to find which of their genes had changed as a result of time-restricted feeding. They identified three genetic pathways that appear to be involved: the TCP-1 ring complex chaperonin, which helps proteins fold; mitochondrial electron transport chain complexes (mETC); and a suite of genes responsible for the body's circadian rhythm.
Melkani and Gill repeated their experiments using mutant strains of flies with nonfunctional versions of the TCP-1 and circadian rhythm genes. In these flies, time-restricted feeding granted no health benefits, strengthening the case that these genetic pathways play key roles.”
There is also a bunch of stuff about regulation of circadian rhythm by meal times. Like, when you are traveling between time zones and want to adjust quickly, be sure to eat meals at the normal time for that time zone.
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