"Unexpectedly, it was recently found that hair follicle regeneration in mouse wounds could be stimulated with secreted factors of the fibroblast growth factor (FGF) and Wingless (WNT) signaling pathways (5). Plikus et al. now make the important finding that hair follicles can change the fate of myofibroblasts (a known cellular player in scarring) into adipocytes through a signaling pathway that depends on bone morphogenetic protein (BMP). Therefore, combinatorial WNT, FGF, and BMP treatment could present a biphasic strategy for scarless wound healing by first stimulating regrowth of hair follicles that would then induce differentiation of scarforming myofibroblasts into adipocytes (see the figure). Intriguingly, the authors found that myofibroblasts isolated from keloid patients also could be induced to become adipocytes by exposure to BMP."
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